PRIDE 研究
前瞻性，盲性，针对599位到麻省总医院急症室主诉呼吸困难患者的研究Januzzi et al, Am J Cardiol 2005;95:948急性呼吸困难中HF的最佳独立预测因素预测因素NT-proBNP升高胸片间质水肿OR44.011.095% CI21.0-91.04.5-26.0P值<.001<.001端坐呼吸袢利尿剂的应用体检有啰音年龄(每年)咳嗽发热9.63.42.41.03.43.174.0-23.01.8-6.41.2-5.21.01-1.05.23-.83.05-.50<.001.01.05.01.05.03Januzzi et al, Am J Cardiol 2005;95:948NT-proBNP诊断心衰准确性优于临床判断10.90.8NT-proBNP versus Clinical Judgment, P=.006Combined versus NT-proBNP, P=.04Combined versus Clinical Judgment, P<.001Combined, AUC=0.96NT-proBNP, AUC=0.94Clinical Judgment, AUC=0.90敏感度(真阳性)0.70.60.50.40.30.20.1000.20.40.60.811 –特异性(假阳性)截定点900 pg/mL能为在呼吸困难患者中诊断急性心力衰竭提供极好的准确性
截定点300 pg/mL450 pg/mL600 pg/mL900 pg/mL1000 pg/mL敏感性99????%特异性68v???%PPV62hsvx%NPV 99????%准确性79????%?独立于年龄Januzzi et al, Am J Cardiol 2005;95:948
