例二
1) s-BuLi Chiral baseNBocChiral base:2) TMSClNTMSBoce e = 96%HNNH34
8.3.2 不对称质子化
例一
OHOLiORi-PrCO2MeRR = Bn83% ee (87% Y)
例二
Me1) s-BuLI2) Chiral baseArCHCON(Pr-i)ArCON(Pr-i)223) BF3. Et2O82% eeMeAr = (6-MeO)-2-Naphthane; Chiral base =NNMe2H
35
例三
OXracemicBase =8.3.3 BINAL-H（ref. 3） OH LiAl OOR'
(S)-BINAL-H
1) n-BuliO2) BaseX84-99%H3CPhNi-PrOHMe
OHLiAlOOR'(R)-BINAL-H36
(S)-BINAL-HRHOH R CH3 95C2H5 98n-C3H7n-C4H9OROAlHArOLiOR'more stable(R)-BINAL-HRROOHHe e (%)OArOAlHROLiOR'less stable37
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